Agpat4 Gene Summary [Mouse]
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in phospholipid metabolic process. Located in endoplasmic reticulum. Is active in mitochondrial outer membrane. Is expressed in several structures, including nervous system; skin; stomach; and testis. Orthologous to human AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agpat4 |
| Official Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) [Source:MGI Symbol;Acc:MGI:1915512] |
| Ensembl ID | ENSMUSG00000023827 |
| Bio databases IDs | |
| Aliases | 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) |
| Synonyms | 1500003P24Rik, 1-acylglycerol-3-phosphate O-acyltransferase 4, 1-AGPAT4, dJ473J16.2, LPAAT4, LPAAT-delta, LPAAT-δ, LPLAT4, LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE delta, LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE δ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agpat4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- lysophosphatidic acid acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
- Acyltransferase C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- coronary artery disease
- cardiovascular disorder
- angina pectoris
- androgenic alopecia
- osteoarthritis
- myocardial infarction
- Rett syndrome
regulates
- phospholipid
- phosphatidic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agpat4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid biosynthetic process
- CDP-diacylglycerol biosynthetic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endomembrane system
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- protein binding