Ffar2 Gene Summary [Mouse]
Enables G protein-coupled receptor activity. Involved in several processes, including leukocyte chemotaxis involved in inflammatory response; positive regulation of cytokine production; and regulation of insulin secretion. Is active in plasma membrane. Is expressed in pancreas; pancreas epithelium; superior cervical ganglion; and testis. Orthologous to human FFAR2 (free fatty acid receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ffar2 |
| Official Name | free fatty acid receptor 2 [Source:MGI Symbol;Acc:MGI:2441731] |
| Ensembl ID | ENSMUSG00000051314 |
| Bio databases IDs | |
| Aliases | free fatty acid receptor 2 |
| Synonyms | Ffa2, FFA2R, free fatty acid receptor 2, GPCR43, GPR43, Lssig |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ffar2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ffar2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- polycystic ovary syndrome
- lung cancer
regulates
- D-glucose
- interferon alpha
- IL6
- CXCL8
- lipid
- Ca2+
- insulin
- p38 MAPK
- ERK1/2
- CREB
role in cell
- production in
- activation in
- expression in
- phosphorylation in
- proliferation
- differentiation
- activity
- formation
- response by
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ffar2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- G-protein coupled receptor signaling pathway
- regulation of peptide hormone secretion
- phospholipase C-activating G-protein coupled receptor signaling pathway
- fat cell differentiation
- negative regulation of insulin secretion
- mucosal immune response
- leukocyte chemotaxis involved in inflammatory response
- regulation of acute inflammatory response
- cell surface pattern recognition receptor signaling pathway
- positive regulation of cytokine production involved in immune response
- positive regulation of interleukin-8 production
- cellular response to fatty acid
- positive regulation of acute inflammatory response to non-antigenic stimulus
- glucose homeostasis
- positive regulation of insulin secretion
- positive regulation of chemokine production
Cellular Component
Where in the cell the gene product is active
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- lipid binding