Cacng1 Gene Summary [Mouse]
Enables voltage-gated calcium channel activity. Acts upstream of or within calcium ion transmembrane transport; establishment of localization in cell; and sarcoplasmic reticulum calcium ion transport. Predicted to be located in T-tubule. Predicted to be part of L-type voltage-gated calcium channel complex. Is expressed in brain; heart; retina; and spinal cord. Human ortholog(s) of this gene implicated in malignant hyperthermia. Orthologous to human CACNG1 (calcium voltage-gated channel auxiliary subunit gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacng1 |
| Official Name | calcium channel, voltage-dependent, gamma subunit 1 [Source:MGI Symbol;Acc:MGI:1206582] |
| Ensembl ID | ENSMUSG00000020722 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, gamma subunit 1 |
| Synonyms | Cacng, CACNLG, calcium channel, voltage-dependent, gamma subunit 1, calcium channel, voltage-dependent, γ subunit 1, calcium voltage-gated channel auxiliary subunit gamma 1, calcium voltage-gated channel auxiliary subunit γ 1, Dihydropyridine receptor γ 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacng1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- PMP-22/EMP/MP20/Claudin family
- protein binding
- ion channel
- calcium channel regulator
Pathways
Biological processes and signaling networks where the Cacng1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Estrogen Receptor Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Serotonin Receptor Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular death
- hypertension
- essential hypertension
- myocardial infarction
- stroke
- COVID-19
- atrioventricular nodal reentry tachycardia
- coronary artery vasospasm
- paroxysmal supraventricular tachycardia
- atrioventricular reciprocating tachycardia
regulates
- Ca2+
- L-type calcium channel
role in cell
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- sarcolemma
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacng1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sarcoplasmic reticulum calcium ion transport
- calcium ion transmembrane transport
- establishment of localization in cell
- positive regulation of muscle contraction
Cellular Component
Where in the cell the gene product is active
- T-tubule
- sarcolemma
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium channel regulator activity
- voltage-gated calcium channel activity