Klhl12 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including COPII vesicle coating; mesenchymal cell differentiation; and protein monoubiquitination. Predicted to be located in centriolar satellite and intracellular membrane-bounded organelle. Predicted to be part of COPII vesicle coat and Cul3-RING ubiquitin ligase complex. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human KLHL12 (kelch like family member 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Klhl12 |
| Official Name | kelch-like 12 [Source:MGI Symbol;Acc:MGI:2385619] |
| Ensembl ID | ENSMUSG00000026455 |
| Bio databases IDs | |
| Aliases | kelch-like 12 |
| Synonyms | C3IP1, DKIR, kelch-like 12, kelch-like family member 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- centrosome
- cytosol
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- neural crest cell development
- Wnt receptor signaling pathway
- protein monoubiquitination
- neural crest formation
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- intracellular membrane-bounded organelle
- cytosol
- ER to Golgi transport vesicle
- Cul3-RING ubiquitin ligase complex
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding