Gucy2f Gene Summary [Mouse]
Predicted to enable guanylate cyclase activity; identical protein binding activity; and peptide receptor activity. Involved in detection of light stimulus involved in visual perception. Located in rod photoreceptor outer segment. Is expressed in nervous system and sensory organ. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gucy2f |
| Official Name | guanylate cyclase 2f [Source:MGI Symbol;Acc:MGI:105119] |
| Ensembl ID | ENSMUSG00000042282 |
| Bio databases IDs | |
| Aliases | guanylate cyclase 2f |
| Synonyms | A930002I06, CYGF, GC2, GC-F, guanylate cyclase 2F, guanylate cyclase 2F, retinal, GUC2DL, GUC2F, RETGC-2, ROS-GC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gucy2f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Receptor family ligand binding region
- Protein kinase (unclassified specificity)
- signaling receptor activity
- Protein tyrosine and serine/threonine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- binding protein
- Protein Kinases, catalytic domain
- Type 1 periplasmic binding fold superfamily
- guanylate cyclase
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Gucy2f gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Endothelin-1 Signaling
- Gap Junction Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Phototransduction Pathway
- Relaxin Signaling
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- outer nuclear membrane
- photoreceptor outer segments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gucy2f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP-mediated signaling
- cGMP biosynthetic process
- detection of light stimulus involved in visual perception
- receptor guanylyl cyclase signaling pathway
- visual perception
- regulation of rhodopsin mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- peptide receptor activity
- identical protein binding
- signaling receptor activity
- guanylate cyclase activity
- protein kinase activity
- adenylate cyclase activity