Lbh Gene Summary [Mouse]
Involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of mammary stem cell proliferation; and positive regulation of somatic stem cell division. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including gut; heart; limb bud; mesendoderm; and nervous system. Orthologous to human LBH (LBH regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lbh |
| Official Name | limb-bud and heart [Source:MGI Symbol;Acc:MGI:1925139] |
| Ensembl ID | ENSMUSG00000024063 |
| Bio databases IDs | |
| Aliases | limb-bud and heart |
| Synonyms | 1810009F10Rik, 6720416L16Rik, Cl2, LBH regulator of WNT signaling pathway, limb-bud and heart, LOC100048380, MSTP014 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lbh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- Cardiac transcription factor regulator, Developmental protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphatic neoplasia
- epithelial neoplasia
- epithelial cancer
- diffuse large B-cell lymphoma
- glioblastoma
- lung adenocarcinoma formation
- liver cancer
- hepatocellular carcinoma
- COVID-19
role in cell
- phosphorylation in
- expression in
- damage in
- differentiation
- cell cycle progression
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lbh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of stem cell differentiation
- negative regulation of intracellular estrogen receptor signaling pathway
- mammary gland epithelial cell differentiation
- positive regulation of mammary stem cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding