Mybl1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and promoter-specific chromatin binding activity. Involved in male meiosis I; positive regulation of DNA-templated transcription; and spermatogenesis. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human MYBL1 (MYB proto-oncogene like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mybl1 |
| Official Name | myeloblastosis oncogene-like 1 [Source:MGI Symbol;Acc:MGI:99925] |
| Ensembl ID | ENSMUSG00000025912 |
| Bio databases IDs | |
| Aliases | myeloblastosis oncogene-like 1 |
| Synonyms | A-MYB, G1-419-6, LOC645895, MYB proto-oncogene like 1, myeloblastosis oncogene-like 1, repro9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mybl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- negative regulation of transactivation domain
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- chromatin binding
- sequence-specific DNA binding
- core domain, functional
- C-myb, C-terminal
- negative regulation of DNA-binding domain
- Myb repeat
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- Myb-like DNA-binding domain
- LMSTEN motif
- charged domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- colorectal cancer
- epithelial cancer
- growth failure
- small cell lung cancer
- glioma
- glioma formation
- systemic autoimmune syndrome
- leiomyoma
- leiomyomatosis
role in cell
- growth
- number
- apoptosis
- proliferation
- differentiation
- double-stranded DNA break repair
- S phase
- synapsis
- double-stranded DNA break repair in
- synapsis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mybl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- spermatogenesis
- male meiosis I
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity