Syt4 Gene Summary [Mouse]
The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Syt4 |
| Official Name | synaptotagmin IV [Source:MGI Symbol;Acc:MGI:101759] |
| Ensembl ID | ENSMUSG00000024261 |
| Bio databases IDs | |
| Aliases | synaptotagmin IV |
| Synonyms | HsT1192, synaptotagmin 4, Synaptotagmin IV, SytIV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syt4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- calcium ion binding
- calcium-dependent phospholipid binding
- clathrin binding
- protein binding
- syntaxin binding
- binding protein
- syntaxin-3 binding
- syntaxin-1 binding
- transmembrane domain
- protein homodimerization
- Protein kinase C conserved region 2 (CalB)
- protein heterodimerization
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- schizophrenia
- weight gain
role in cell
- expression in
- fusion
- exocytosis
- transport
- endocytosis by
- elongation in
- elongation
- extension
- presence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- exocytic vesicle
- cell periphery
- somatodendritic region
- perinuclear region
- microvesicles
- cellular membrane
- vacuole
- Plasma Membrane
- vesicles
- Golgi Apparatus
- microtubule tips
- secretory granule membrane
- synaptic membrane
- plasma membrane projections
- Golgi membrane
- trans Golgi network
- cis Golgi networks
- synaptic vesicles
- neurites
- nerve ending
- dense-core vesicles
- secretory granules
- perikaryon
- axons
- dendrites
- astrocyte projections
- immature secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syt4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dopamine secretion
- negative regulation of protein secretion
- negative regulation of calcium ion-dependent exocytosis
- positive regulation of calcium ion-dependent exocytosis
- memory
- regulation of vesicle fusion
- calcium ion-dependent exocytosis of neurotransmitter
- negative regulation of catecholamine secretion
- negative regulation of short-term neuronal synaptic plasticity
- vesicle fusion
- cell differentiation
- regulation of endocytosis
- positive regulation of glutamate secretion
- negative regulation of synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- dendrite
- perinuclear region of cytoplasm
- Golgi membrane
- synapse
- synaptic vesicle membrane
- neuronal cell body
- axon
- plasma membrane
- dense core granule membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein binding
- calcium ion binding
- SNARE binding
- clathrin binding
- calcium-dependent phospholipid binding