Stx3 Gene Summary [Mouse]
Predicted to enable SNAP receptor activity; SNARE binding activity; and arachidonate binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane; modulation of chemical synaptic transmission; and vesicle-mediated transport in synapse. Acts upstream of or within exocytosis and long-term synaptic potentiation. Located in several cellular components, including cytoplasmic vesicle; photoreceptor inner segment; and photoreceptor outer segment. Part of SNARE complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx3 |
| Official Name | syntaxin 3 [Source:MGI Symbol;Acc:MGI:103077] |
| Ensembl ID | ENSMUSG00000041488 |
| Bio databases IDs | |
| Aliases | syntaxin 3 |
| Synonyms | DIAR12, MVID2, RDMVID, STX3A, Syn-3, syntaxin 3, Syntaxin 3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- coiled-coil domain
- arachidonic acid binding
- protein binding
- SynN
- cytoplasmic domain
- SNARE domain
- Helical region found in SNAREs
- transmembrane domain
- Syntaxin
- SNARE motif
- golgi targeting sequence
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- uterine leiomyoma
- retinal dystrophy and microvillus inclusion disease
- HER2 negative hormone receptor negative breast cancer
- systemic sclerosis
- leiomyomatosis
- diarrhea with microvillus atrophy type 12
role in cell
- proliferation
- survival
- upregulation in
- abnormal morphology
- adhesion
- fusion
- exocytosis by
- chemotaxis
- morphogenesis
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- invadopodia
- presynaptic regions
- postsynaptic region
- cellular membrane
- vacuole
- intercellular junctions
- granules
- cytosol
- apical membrane
- nucleoplasm
- zymogen granules
- growth cone
- neurites
- nerve ending
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- vacuolar apical compartments
- melanosomes
- azurophil granules
- specific granules
- secretory granules
- dendrites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization at cell surface
- neuron projection development
- vesicle docking
- synaptic vesicle fusion to presynaptic membrane
- positive regulation of cell proliferation
- regulation of gene expression
- long-term synaptic potentiation
- positive regulation of cell adhesion
- organelle membrane fusion
- intracellular protein transport
- positive regulation of chemotaxis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- presynaptic active zone membrane
- neuron projection
- vacuole
- zymogen granule membrane
- plasma membrane
- photoreceptor outer segment
- growth cone
- dendrite
- nucleus
- cell-cell junction
- extracellular vesicular exosome
- melanosome
- specific granule
- azurophil granule
- endomembrane system
- SNARE complex
- photoreceptor inner segment
- apical plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding
- arachidonic acid binding