Asap2 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and liver. Orthologous to human ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Asap2 |
| Official Name | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [Source:MGI Symbol;Acc:MGI:2685438] |
| Ensembl ID | ENSMUSG00000052632 |
| Bio databases IDs | |
| Aliases | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 |
| Synonyms | 6530401G17RIK, AMAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2, CENTB3, DDEF2, Development and differentiation enhancing factor 2, Gm1523, Gm592, PAG3, PAP, Pap Alpha, Pap-α, SHAG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Bin/Amphiphysin/Rvs domain
- Arf-GAP domain
- proline rich domain
- Ankyrin repeat
- Src Homology 3 domain superfamily
- BAR domain of APPL family
- Putative GTP-ase activating proteins for the small GTPase, ARF
- PH domain
- Putative GTPase activating protein for Arf
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neuroblastoma
- osteoarthritis
- coronary artery disease
- neuroblastoma formation
- widespread chronic pain
- acute myeloid leukemia
- bipolar disorder
role in cell
- migration
- phagocytosis
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
- Plasma Membrane
- Golgi Apparatus
- cytosol
- plasma membrane projections
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asap2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity