Spire1 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and intracellular transport. Acts upstream of or within Golgi vesicle transport; behavioral fear response; and dendritic spine development. Located in Golgi apparatus; cell cortex; and cytoplasmic vesicle membrane. Colocalizes with cleavage furrow. Is expressed in several structures, including central nervous system; genitourinary system; intestine; liver; and spleen. Orthologous to human SPIRE1 (spire type actin nucleation factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spire1 |
| Official Name | spire type actin nucleation factor 1 [Source:MGI Symbol;Acc:MGI:1915416] |
| Ensembl ID | ENSMUSG00000024533 |
| Bio databases IDs | |
| Aliases | spire type actin nucleation factor 1 |
| Synonyms | 6030430B19Rik, Spir-1, spire-type actin nucleation factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spire1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- Protein Kinases, catalytic domain
- WH2
- protein binding
- Kinase non-catalytic C-lobe domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early missed abortion
regulates
- actin
- QKI
- GALNT3
- Vsvg
role in cell
- quantity
- formation
- organization
- localization
- upregulation in
- development
- polymerization
- positioning in
- transport
- positioning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cell cortex
- Golgi Apparatus
- cytosol
- mitochondrial outer membrane
- nucleoplasm
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spire1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polar body extrusion after meiotic divisions
- cleavage furrow formation
- formin-nucleated actin cable assembly
- intracellular transport
- protein transport
- actin filament polymerization
- positive regulation of mitochondrial fission
- vesicle-mediated transport
- innate immune response
- establishment of meiotic spindle localization
- actin nucleation
- actin filament network formation
- positive regulation of double-strand break repair
- actin cytoskeleton organization
- Golgi vesicle transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- cytoskeleton
- cleavage furrow
- cell cortex
- cytosol
- mitochondrial outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- microtubule binding