Rps14 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in several processes, including erythrocyte differentiation; negative regulation of transcription by RNA polymerase II; and ribosomal small subunit biogenesis. Located in mitochondrion. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in early conceptus; metanephros; and telencephalon. Human ortholog(s) of this gene implicated in chromosome 5q deletion syndrome. Orthologous to human RPS14 (ribosomal protein S14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps14 |
| Official Name | ribosomal protein S14 [Source:MGI Symbol;Acc:MGI:98107] |
| Ensembl ID | ENSMUSG00000024608 |
| Bio databases IDs | |
| Aliases | ribosomal protein S14 |
| Synonyms | 2600014J02Rik, EMTB, ribosomal protein S14, S14, uS11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- mRNA 5' UTR binding
- protein binding
- translation regulator
- Ribosomal protein S11
- RNA binding
Pathways
Biological processes and signaling networks where the Rps14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- celiac disease
- anemia
- dysplasia
- myelodysplastic syndrome with isolated del(5q)
- Sengers syndrome
regulated by
- lipopolysaccharide
- palmitic acid
- beta-estradiol
- L-triiodothyronine
- polyunsaturated fatty acids
- delta-aminolevulinic acid
- arachidonic acid
- PDGF-BB
- MYC
- Influenza A virus (A/Bangkok/RX73(H3N2))
role in cell
- cell death
- expression in
- formation
- formation in
- proliferation
- differentiation
- quantity
- size
- outgrowth
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pre-ribosome
- cellular membrane
- ribosome
- cytosol
- granular components
- nucleoplasm
- nucleoli
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- negative regulation of transcription from RNA polymerase II promoter
- erythrocyte differentiation
- maturation of SSU-rRNA
- cytoplasmic translation
- ribosomal small subunit biogenesis
- ribosomal small subunit assembly
- translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- small-subunit processome
- extracellular vesicular exosome
- cytosolic ribosome
- focal adhesion
- cytoplasm
- cytosolic small ribosomal subunit
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- translation regulator activity
- RNA binding
- protein binding
- structural constituent of ribosome
- mRNA 5'-UTR binding