Htr7 Gene Summary [Mouse]
Enables G protein-coupled serotonin receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Predicted to be located in axon terminus; neuronal cell body; and synaptic vesicle. Predicted to be active in dendrite; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; blastocyst; brain; immune system; and reproductive system. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr7 |
| Official Name | 5-hydroxytryptamine (serotonin) receptor 7 [Source:MGI Symbol;Acc:MGI:99841] |
| Ensembl ID | ENSMUSG00000024798 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine (serotonin) receptor 7 |
| Synonyms | 5-HT7, 5HTR7, 5-HT-X, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine (serotonin) receptor 7, LOC103694905, Serotonin receptor 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Htr7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neurotransmitter receptor
- serotonin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Htr7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MATR3
- ligand
- S 18327
- aripiprazole
- vortioxetine
- amoxapine
- SLV-313
- lurasidone
- amisulpride
- methysergide
disease
- postoperative nausea and vomiting
- non-insulin-dependent diabetes mellitus
- schizophrenia
- major depression
- cardiovascular disorder
- hyperlipidemia
- dextran sodium sulfate-induced colitis
- Parkinson disease
- Alzheimer disease
- psychosis
regulated by
- SLC6A4
- clozapine
- olanzapine
- beta-estradiol
- concanavalin a
- fluvoxamine
- 5-hydroxytryptamine
- tetradecanoylphorbol acetate
- nortriptyline
- tamsulosin
role in cell
- expression in
- migration
- formation
- differentiation
- development
- generation in
- quantity
- cell rounding
- opening in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- trans Golgi network
- nucleoplasm
- synaptic vesicles
- perikaryon
- dendrites
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Htr7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- smooth muscle contraction
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- blood circulation
- synaptic transmission
- vasoconstriction
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- trans-Golgi network membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity