LOC103694905 Gene Summary [Rat]

Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including axon terminus; neuronal cell body; and synaptic vesicle. Is active in postsynaptic membrane and presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Nonsense Mediated Decay
Official Symbol
LOC103694905
Official Name
5-hydroxytryptamine receptor 7 [Source:RGD Symbol;Acc:9265298]
Ensembl ID
ENSRNOG00000018827
Bio databases IDs NCBI: 65032 Ensembl: ENSRNOG00000018827
Aliases 5-hydroxytryptamine receptor 7
Synonyms 5-HT7, 5HTR7, 5-HT-X, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine (serotonin) receptor 7, LOC103694905, Serotonin receptor 7
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc103694905 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • neurotransmitter receptor
  • serotonin receptor
  • 7 transmembrane receptor (rhodopsin family)
  • protein binding
  • seven-transmembrane G protein-coupled receptor superfamily
  • transmembrane receptor

Pathways

Biological processes and signaling networks where the Loc103694905 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • MATR3
  • ligand
  • S 18327
  • aripiprazole
  • vortioxetine
  • amoxapine
  • SLV-313
  • lurasidone
  • amisulpride
  • methysergide
disease
  • postoperative nausea and vomiting
  • non-insulin-dependent diabetes mellitus
  • schizophrenia
  • major depression
  • cardiovascular disorder
  • hyperlipidemia
  • dextran sodium sulfate-induced colitis
  • Parkinson disease
  • Alzheimer disease
  • psychosis
regulated by
  • SLC6A4
  • clozapine
  • olanzapine
  • beta-estradiol
  • concanavalin a
  • fluvoxamine
  • 5-hydroxytryptamine
  • tetradecanoylphorbol acetate
  • nortriptyline
  • tamsulosin
regulates
  • ERK1/2
  • PRKCE
  • FOS
  • p38 MAPK
  • IL1B
  • 5-hydroxytryptamine
  • Ca2+
  • IL6
  • cyclic AMP
  • IL12 (complex)
role in cell
  • expression in
  • migration
  • formation
  • differentiation
  • development
  • generation in
  • quantity
  • cell rounding
  • opening in
  • length

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cilia
  • cellular membrane
  • presynaptic membrane
  • postsynaptic membrane
  • basolateral membrane
  • trans Golgi network
  • nucleoplasm
  • synaptic vesicles
  • perikaryon
  • dendrites
  • axon terminals
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Loc103694905 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • smooth muscle contraction
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • blood circulation
  • synaptic transmission
  • vasoconstriction
  • circadian rhythm

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • synapse
  • trans-Golgi network membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • neurotransmitter receptor activity
  • serotonin receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.