HTR7 Gene Summary [Human]
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HTR7 |
| Official Name | 5-hydroxytryptamine receptor 7 [Source:HGNC Symbol;Acc:HGNC:5302] |
| Ensembl ID | ENSG00000148680 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 7 |
| Synonyms | 5-HT7, 5HTR7, 5-HT-X, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine (serotonin) receptor 7, LOC103694905, Serotonin receptor 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neurotransmitter receptor
- serotonin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the HTR7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MATR3
- ligand
- S 18327
- aripiprazole
- vortioxetine
- amoxapine
- SLV-313
- lurasidone
- amisulpride
- methysergide
disease
- postoperative nausea and vomiting
- non-insulin-dependent diabetes mellitus
- schizophrenia
- major depression
- cardiovascular disorder
- hyperlipidemia
- dextran sodium sulfate-induced colitis
- Parkinson disease
- Alzheimer disease
- psychosis
regulated by
- SLC6A4
- clozapine
- olanzapine
- beta-estradiol
- concanavalin a
- fluvoxamine
- 5-hydroxytryptamine
- tetradecanoylphorbol acetate
- nortriptyline
- tamsulosin
role in cell
- expression in
- migration
- formation
- differentiation
- development
- generation in
- quantity
- cell rounding
- opening in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- trans Golgi network
- nucleoplasm
- synaptic vesicles
- perikaryon
- dendrites
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- smooth muscle contraction
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- blood circulation
- synaptic transmission
- vasoconstriction
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- trans-Golgi network membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity