LOC100911854 Gene Summary [Rat]
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]
Details
| Type | Protein Coding |
| Official Symbol | LOC100911854 |
| Official Name | mannose-binding protein C-like [Source:RGD Symbol;Acc:6490749] |
| Ensembl ID | ENSRNOG00000050305 |
| Bio databases IDs | |
| Aliases | mannose-binding protein C-like |
| Synonyms | Ab2-001, Ab2-011, COLEC1, HSMBPC, L-MBP, LOC100911854, MANNOSE-binding, mannose binding lectin 2, mannose-binding lectin (protein C) 2, MBL, MBL2D, MBL-C, MBP, MBP1, MBP-C, MBPD, RARF/P28A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100911854 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- collagen-like domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protease binding
- calcium ion binding
- protein binding
- receptor binding
- identical protein binding
- mannose binding
- phosphatidylinositol binding
- galactose binding
- Lectin C-type domain
- Collagen triple helix repeat (20 copies)
- neck domain
Pathways
Biological processes and signaling networks where the Loc100911854 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection
- rheumatoid arthritis
- liver cancer
- systemic inflammatory response syndrome
- mannose-binding lectin deficiency
- organismal death
- Staphylococcus aureus pneumonia
- systemic lupus erythematosus
- epithelial cancer
role in cell
- binding
- uptake
- quantity
- growth
- proliferation
- metastatic potential
- attachment
- number
- phagocytosis by
- recognition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- endoplasmic reticulum lumen
- rough endoplasmatic reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100911854 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral reproduction
- defense response to bacterium
- acute-phase response
- opsonization
- surfactant homeostasis
- killing by host of symbiont cells
- cell surface pattern recognition receptor signaling pathway
- response to oxidative stress
- complement activation, classical pathway
- innate immune response
- complement activation, lectin pathway
- proteolysis
- positive regulation of phagocytosis
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- external side of plasma membrane
- multivesicular body
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- mannose binding
- calcium-dependent protein binding
- receptor binding