Tll2 Gene Summary [Mouse]
Predicted to enable metalloendopeptidase activity. Acts upstream of or within negative regulation of skeletal muscle tissue growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in diencephalon floor plate; diencephalon lateral wall ventricular layer; and pituitary gland. Orthologous to human TLL2 (tolloid like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tll2 |
| Official Name | tolloid-like 2 [Source:MGI Symbol;Acc:MGI:1346044] |
| Ensembl ID | ENSMUSG00000025013 |
| Bio databases IDs | |
| Aliases | tolloid-like 2 |
| Synonyms | KIAA0932, LOC680012, RGD1559756, Tll2b, tolloid-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tll2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZnMc
- protease domain
- serine endopeptidase
- CUB
- metalloprotease domain
- peptidase
- Astacin (Peptidase family M12A)
- EGF domain
- Zinc-dependent metalloprotease
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- attention deficit hyperactivity disorder
- major depression
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- insomnia
- idiopathic scoliosis
- Takayasu arteritis
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tll2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of skeletal muscle tissue growth
- cell differentiation
- protein processing
- collagen fibril organization
- dorsal/ventral pattern formation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- calcium ion binding
- serine-type endopeptidase activity
- metalloendopeptidase activity