Lamc2 Gene Summary [Mouse]
Enables heparin binding activity. Predicted to be involved in several processes, including axon guidance; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; basement membrane; central nervous system; genitourinary system; and skin. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamc2 |
| Official Name | laminin, gamma 2 [Source:MGI Symbol;Acc:MGI:99913] |
| Ensembl ID | ENSMUSG00000026479 |
| Bio databases IDs | |
| Aliases | laminin, gamma 2 |
| Synonyms | B2T, BM600, CSF, CSF 140 kDa subunit, EBR2, EBR2A, JEB3A, JEB3B, KALININ, LAMB2T, Laminin5 gamma2, Laminin B2t chain, Laminin Gamma 2, laminin, gamma 2, laminin subunit gamma 2, laminin subunit γ 2, Laminin γ 2, laminin, γ 2, LAMNB2, Lm gamma 2, Lm γ 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Laminin-type epidermal growth factor-like domai
- laminin domain V
- Laminin B (Domain IV)
- PspA/IM30 family
- ClyA-like
- protein binding
- heparin binding
- Laminin EGF domain
- Laminin Domain I
- EGF_CA
Pathways
Biological processes and signaling networks where the Lamc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- epithelial cancer
- epithelial neoplasia
- cancer
- head and neck cancer
- head and neck neoplasia
- breast cancer
- epidermolysis bullosa letalis
- intermediate junctional epidermolysis bullosa type 3A
role in cell
- expression in
- binding in
- phosphorylation in
- cell viability
- apoptosis
- proliferation
- production in
- adhesion
- migration
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- cell cortex
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- extracellular matrix
- basal lamina
- interphotoreceptor matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- epidermis development
- cell adhesion
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- cell cortex
- laminin-2 complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- heparin binding
- extracellular matrix structural constituent