Taf5 Gene Summary [Mouse]
Enables DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Is expressed in embryo and tail. Orthologous to human TAF5 (TATA-box binding protein associated factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf5 |
| Official Name | TATA-box binding protein associated factor 5 [Source:MGI Symbol;Acc:MGI:2442144] |
| Ensembl ID | ENSMUSG00000025049 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 5 |
| Synonyms | 6330528C20RIK, TAF2D, TAF(II)100, TAFII-100, Tata box binding protein associated factor, 100kd, TATA-box binding protein associated factor 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TAF5 N-terminal domain 2
- transcription regulator
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- chromatin binding
- protein binding
- general RNA polymerase II transcription factor
- identical protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Taf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
role in cell
- JQ1-sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- actin cytoskeleton
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription initiation from RNA polymerase II promoter
- regulation of DNA repair
- transcription initiation, DNA-dependent
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- transcription factor TFTC complex
- actin cytoskeleton
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- general RNA polymerase II transcription factor activity