Entpd7 Gene Summary [Mouse]
Enables ribonucleoside triphosphate phosphatase activity. Involved in T-helper 17 cell differentiation and regulation of immune response. Predicted to be located in cytoplasmic vesicle membrane and nucleus. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Entpd7 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 7 [Source:MGI Symbol;Acc:MGI:2135885] |
| Ensembl ID | ENSMUSG00000025192 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 7 |
| Synonyms | 1810012B13Rik, 1810020C02Rik, 2810003F23Rik, ectonucleoside triphosphate diphosphohydrolase 7, LALP1, LOC100911700, Lysal2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Entpd7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- nucleoside-diphosphatase
- GTPase
- enzyme
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- infection by bacteria
regulates
- APP
- guanosine triphosphate
- CTP
- ribonucleoside diphosphate
- UTP
- ribonucleoside triphosphate
role in cell
- number
- differentiation
- production in
- abnormal number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endocytic vesicle membrane
- cytoplasmic vesicle membrane
- intracellular membranes
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Entpd7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UTP catabolic process
- CTP metabolic process
- GTP metabolic process
- UDP catabolic process
- CTP catabolic process
- T-helper 17 cell differentiation
- nucleobase-containing small molecule catabolic process
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- membrane
- Golgi apparatus
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- CTPase activity
- uridine-diphosphatase activity
- metal ion binding
- GTPase activity
- guanosine-diphosphatase activity
- nucleoside-triphosphatase activity