Slc33a1 Gene Summary [Mouse]
Predicted to enable acetyl-CoA transmembrane transporter activity and protein homodimerization activity. Predicted to be involved in acetyl-CoA transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including brain; heart; liver; metanephros; and spleen. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 42. Orthologous to human SLC33A1 (solute carrier family 33 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc33a1 |
| Official Name | solute carrier family 33 (acetyl-CoA transporter), member 1 [Source:MGI Symbol;Acc:MGI:1332247] |
| Ensembl ID | ENSMUSG00000027822 |
| Bio databases IDs | |
| Aliases | solute carrier family 33 (acetyl-CoA transporter), member 1 |
| Synonyms | ACATN, AT-1, CCHLND, D630022N01Rik, HPBDS, LOC100362859, solute carrier family 33 (acetyl-CoA transporter), member 1, solute carrier family 33 member 1, SPG42 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc33a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetyl-CoA transporter
- AmpG-like permease
- Major Facilitator Superfamily
- protein homodimerization
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- localization-related epilepsy
- Waldenström macroglobulinemia
- neoplasia
- dermatitis
- congenital cataracts, hearing loss, and neurodegeneration
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- cancer
role in cell
- degeneration
- acetylation in
- activation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc33a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- acetyl-CoA transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- acetyl-CoA transporter activity