Lbx1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including heart looping; negative regulation of glutamatergic neuron differentiation; and neuron differentiation. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; skeletal musculature; and urinary system. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human LBX1 (ladybird homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lbx1 |
| Official Name | ladybird homeobox 1 [Source:MGI Symbol;Acc:MGI:104867] |
| Ensembl ID | ENSMUSG00000025216 |
| Bio databases IDs | |
| Aliases | ladybird homeobox 1 |
| Synonyms | CCHS3, homeobox, HPX-6, ladybird homeobox 1, LBX1H, RGD1564197 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lbx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- protein binding
- transcription factor activity
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- congenital central hypoventilation syndrome
- congenital central hypoventilation syndrome 3
role in cell
- quantity
- proliferation
- migration
- innervation
- development
- transactivation in
- differentiation
- fate determination
- commitment
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lbx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- cell proliferation
- neuron fate determination
- negative regulation of cell proliferation
- spinal cord motor neuron differentiation
- heart looping
- anatomical structure morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity