Fitm2 Gene Summary [Mouse]
Enables diacylglycerol binding activity and triglyceride binding activity. Involved in several processes, including fat cell differentiation; intracellular triglyceride homeostasis; and lipid droplet formation. Acts upstream of or within triglyceride storage. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fitm2 |
| Official Name | fat storage-inducing transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:2444508] |
| Ensembl ID | ENSMUSG00000048486 |
| Bio databases IDs | |
| Aliases | fat storage-inducing transmembrane protein 2 |
| Synonyms | AI414861, C20orf142, D930001I22Rik, dJ881L22.2, fat storage-inducing transmembrane protein 2, Fit2, RGD1307696, SIDDIS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fitm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inositol phospholipid synthesis and fat-storage-inducing TM
- pyrophosphatase
- diacylglycerol binding
- enzyme
- protein binding
- triglyceride binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- Siddiqi syndrome
- lipodystrophy
- hyperinsulinism
- acquired partial lipodystrophy
- enteropathy
- sarcoidosis
- weight gain
role in cell
- differentiation
- cell death
- number
- accumulation
- formation in
- quantity
- formation
- accumulation in
- size
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fitm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- positive regulation of sequestering of triglyceride
- cytoskeleton organization
- regulation of cell morphogenesis
- lipid homeostasis
- phospholipid biosynthetic process
- lipid particle organization
- regulation of triglyceride biosynthetic process
- cellular triglyceride homeostasis
- fatty-acyl-CoA catabolic process
- sequestering of triglyceride
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- triglyceride binding
- protein binding
- CoA pyrophosphatase activity
- diacylglycerol binding