Pidd1 Gene Summary [Mouse]
Predicted to enable endopeptidase activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is expressed in brain; liver; nose; and urinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 75. Orthologous to human PIDD1 (p53-induced death domain protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Pidd1 |
| Official Name | p53 induced death domain protein 1 [Source:MGI Symbol;Acc:MGI:1889507] |
| Ensembl ID | ENSMUSG00000025507 |
| Bio databases IDs | |
| Aliases | p53 induced death domain protein 1 |
| Synonyms | 1200011D09Rik, LOC100911519, LRDD, MRT75, p53-induced death domain protein 1, PIDD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pidd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase S68
- Death domain
- death receptor binding
- endopeptidase
- protein phosphatase 1 regulatory subunit 42
- peptidase
- Leucine rich repeat
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
- ZU5 domain
Pathways
Biological processes and signaling networks where the Pidd1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- hereditary disorder
- autosomal recessive intellectual developmental disorder type 75 with neuropsychiatric features and variant lissencephaly
- androgenic alopecia
- mental retardation
- keratoconus
- COVID-19
role in cell
- activation in
- proliferation
- phosphorylation in
- apoptosis
- growth
- cell death
- colony formation
- sumoylation in
- ubiquitination in
- cytostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pidd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- signal transduction
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- apoptotic process
- regulation of I-kappaB kinase/NF-kappaB cascade
- protein autoprocessing
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- response to DNA damage stimulus
- induction of apoptosis via death domain receptors
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- death receptor binding