Asl Gene Summary [Mouse]
Predicted to enable argininosuccinate lyase activity and identical protein binding activity. Involved in L-arginine biosynthetic process and positive regulation of nitric oxide biosynthetic process. Acts upstream of or within ammonia assimilation cycle; locomotory behavior; and post-embryonic development. Predicted to be located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study argininosuccinic aciduria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asl |
| Official Name | argininosuccinate lyase [Source:MGI Symbol;Acc:MGI:88084] |
| Ensembl ID | ENSMUSG00000025533 |
| Bio databases IDs | |
| Aliases | argininosuccinate lyase |
| Synonyms | 2510006M18Rik, argininosuccinate lyase, Arginosuccinase, ASAL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- argininosuccinate lyase
- Lyase class I-like
- lyase
- Argininosuccinate lyase C-terminal
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- argininosuccinate lyase deficiency
- metastasis
- hereditary disorder
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- argininosuccinic aciduria
- nitric oxide deficiency
- neurodevelopmental disorder
role in cell
- expression in
- trimethylation in
- recruitment in
- binding in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- mitochondrial outer membrane
- neurites
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- arginine metabolic process
- positive regulation of nitric oxide biosynthetic process
- locomotory behavior
- arginine biosynthetic process
- urea cycle
- post-embryonic development
- arginine biosynthetic process via ornithine
- ammonia assimilation cycle
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- argininosuccinate lyase activity