Gabpa Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within blastocyst formation; negative regulation of megakaryocyte differentiation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabpa |
| Official Name | GA repeat binding protein, alpha [Source:MGI Symbol;Acc:MGI:95610] |
| Ensembl ID | ENSMUSG00000008976 |
| Bio databases IDs | |
| Aliases | GA repeat binding protein, alpha |
| Synonyms | E4TF1-60, E4TF1A, GA binding protein transcription factor subunit alpha, GA binding protein transcription factor subunit α, GABPalpha, GA repeat binding protein, alpha, GA repeat binding protein, α, NFT2, NRF2, NRF2A, Nrf-2alpha, RCH04A07 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabpa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- SAM (Sterile alpha motif )
- chromatin binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- GA-binding protein alpha chain
- double-stranded DNA binding
- pointed domain
- Ets-domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Gabpa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gout
- organismal death
- Hutchinson-Gilford progeria syndrome
- Down syndrome
- colorectal cancer
role in cell
- activation in
- expression in
- apoptosis
- production in
- invasion by
- differentiation
- growth
- development
- morphology
- neurotransmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabpa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- blastocyst formation
- cell differentiation
- negative regulation of megakaryocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity