Sec11a Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human SEC11A (SEC11 homolog A, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Sec11a |
| Official Name | SEC11 homolog A, signal peptidase complex subunit [Source:MGI Symbol;Acc:MGI:1929464] |
| Ensembl ID | ENSMUSG00000025724 |
| Bio databases IDs | |
| Aliases | SEC11 homolog A, signal peptidase complex subunit |
| Synonyms | 1810012E07Rik, Endopeptidase SP18, Microsomal signal peptidase 18 kda, SEC11 homolog A, signal peptidase complex subunit, SEC11L1, sid2895, Sid2895p, SPC18, SPCS4A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sec11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine endopeptidase
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- epithelial cancer
- bipolar disorder
- melanoma cancer
- liver cirrhosis
- astrocytoma
- glioma formation
- cardiomyopathy
- glioblastoma
- glioblastoma cancer
regulates
role in cell
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sec11a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal peptide processing
- response to virus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- signal peptidase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- peptidase activity