Sf3a1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human SF3A1 (splicing factor 3a subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sf3a1 |
| Official Name | splicing factor 3a, subunit 1 [Source:MGI Symbol;Acc:MGI:1914715] |
| Ensembl ID | ENSMUSG00000002129 |
| Bio databases IDs | |
| Aliases | splicing factor 3a, subunit 1 |
| Synonyms | 1200014H24Rik, 5930416L09Rik, PRP21, PRPF21, SAP114, SF3A120, SF3A p120, splicing factor 3A subunit 1, splicing factor 3a, subunit 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sf3a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- Pre-mRNA splicing factor PRP21 like protein
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- Surp module
- protein binding
- Suppressor-of-White-APricot splicing regulator
- RNA binding
Pathways
Biological processes and signaling networks where the Sf3a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- B-cell non-Hodgkin disease
- non-Hodgkin disease
- lymphomagenesis
- B cell cancer
- mature B-cell neoplasia
- B-cell neoplasia
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- cell death
- cell viability
- splicing by
- replication in
- alternative splicing in
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sf3a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA cis splicing, via spliceosome
- mRNA processing
- nuclear mRNA 3'-splice site recognition
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- spliceosomal complex
- U2-type prespliceosome
- U2-type spliceosomal complex
- U2-type precatalytic spliceosome
- U2 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding