Taf1c Gene Summary [Mouse]
Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly. Predicted to act upstream of or within transcription by RNA polymerase I. Part of RNA polymerase transcription factor SL1 complex. Is expressed in limb and limb mesenchyme. Orthologous to human TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Taf1c |
| Official Name | TATA-box binding protein associated factor, RNA polymerase I, C [Source:MGI Symbol;Acc:MGI:109576] |
| Ensembl ID | ENSMUSG00000031832 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor, RNA polymerase I, C |
| Synonyms | MGC:39976, mTAFI95, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase 1 subunit C, TATA-box binding protein associated factor, RNA polymerase I, C, TATA-box binding protein associated factor, RNA polymerase I subunit C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Taf1c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autism
- chronic periodontal disease
role in cell
- expression in
- replicative senescence
- cellular reprogramming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase I transcriptional preinitiation complex assembly
- transcription initiation from RNA polymerase I promoter
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- RNA polymerase transcription factor SL1 complex
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase I CORE element sequence-specific DNA binding
- protein binding
- core RNA polymerase I binding transcription factor activity