Agfg1 Gene Summary [Mouse]
Predicted to enable DNA binding activity; GTPase activator activity; and zinc ion binding activity. Acts upstream of or within acrosome assembly; intermediate filament organization; and spermatid nucleus differentiation. Located in cell projection; cytoplasmic vesicle; and neuronal cell body. Used to study oligoasthenoteratozoospermia. Orthologous to human AGFG1 (ArfGAP with FG repeats 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agfg1 |
| Official Name | ArfGAP with FG repeats 1 [Source:MGI Symbol;Acc:MGI:1333754] |
| Ensembl ID | ENSMUSG00000026159 |
| Bio databases IDs | |
| Aliases | ArfGAP with FG repeats 1 |
| Synonyms | ArfGAP with FG repeats 1, C130049H11Rik, D730048C23RIK, Hiv1 rev binding, HRB, LOC285086, RAB, RIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agfg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FG repeat
- Putative GTP-ase activating proteins for the small GTPase, ARF
- NPF motif
- protein binding
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Putative GTPase activating protein for Arf
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- systemic lupus erythematosus
- silicosis
- pervasive developmental disorder
- airway hyperresponsiveness
regulates
- insulin
- REV
- ATG9A
- VAMP7
role in cell
- accumulation in
- formation
- differentiation
- formation in
- development
- assembly
- accumulation
- organization
- differentiation in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- outer membranes
- cytosol
- nuclear pores
- cytoplasmic vesicles
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agfg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- acrosome assembly
- spermatid nucleus differentiation
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- cytosol
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- metal ion binding
- GTPase activator activity