Acsl4

Enables long-chain fatty acid-CoA ligase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Acts upstream of or within embryonic process involved in female pregnancy. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; limb mesenchyme; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acsl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Acsl4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Acsl4 gene, providing context for its role in the cell.