Ppm1f Gene Summary [Mouse]
Predicted to enable calmodulin-dependent protein phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including positive regulation of cellular component biogenesis; protein dephosphorylation; and regulation of macromolecule metabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1f |
| Official Name | protein phosphatase 1F (PP2C domain containing) [Source:MGI Symbol;Acc:MGI:1918464] |
| Ensembl ID | ENSMUSG00000026181 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1F (PP2C domain containing) |
| Synonyms | 1110021B16Rik, 4933427B07Rik, CAMKP, CaMKPase, FEM-2, hFEM-2, KIAA0015, mKIAA0015, P2CH, POPX2, protein phosphatase 1F (PP2C domain containing), protein phosphatase, Mg2+/Mn2+ dependent 1F, protein phosphatase, Mg2+/Mn2+ dependent, 1F |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sigma factor PP2C-like phosphatases
- protein tyrosine/serine/threonine phosphatase
- Protein phosphatase 2C
- phosphoprotein phosphatase
- catalytic domain
- protein serine/threonine phosphatase
- protein binding
- phosphatase domain
- Serine/threonine phosphatases, family 2C, catalytic domain
- protein phosphatase
- calcium-dependent protein serine/threonine phosphatase
- phosphatase
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1f gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- diabetic nephropathy
- acute graft-vs-host disease
- hemimegalencephaly
role in cell
- apoptosis
- invasion by
- morphology
- migration
- formation
- formation in
- elongation
- adhesion
- chemotaxis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of growth
- peptidyl-threonine dephosphorylation
- regulation of protein localization
- protein dephosphorylation
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- intrinsic apoptotic signaling pathway
- negative regulation of protein kinase activity
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of protein transport
- peptidyl-serine dephosphorylation
- positive regulation of focal adhesion assembly
- negative regulation of transcription, DNA-dependent
- positive regulation of stress fiber assembly
- positive regulation of gene expression
- negative regulation of peptidyl-serine phosphorylation
- cellular response to xenobiotic stimulus
- positive regulation of cell-substrate adhesion
- positive regulation of epithelial cell migration
- positive regulation of chemotaxis
- negative regulation of cell-cell adhesion mediated by cadherin
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- calmodulin-dependent protein phosphatase activity
- protein binding
- metal ion binding
- protein tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity