ATG16L1 Gene Summary [Human]
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | ATG16L1 |
| Official Name | autophagy related 16 like 1 [Source:HGNC Symbol;Acc:HGNC:21498] |
| Ensembl ID | ENSG00000085978 |
| Bio databases IDs | |
| Aliases | autophagy related 16 like 1 |
| Synonyms | 1500009K01Rik, APG16L, ATG16, ATG16A, ATG16L, autophagy related 16-like 1, FLJ10035, FLJ22677, IBD10, WDR30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATG16L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- beta propeller
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- protein binding activity, bridging
- WD domain, G-beta repeat
- enzyme binding
- coiled-coil domain
- WD40
- enzyme
- protein binding
- identical protein binding
- Prefoldin subunit
- ubiquitin-like protein transferase activity
- WD40 repeats
- prefoldin
- intermediate domain
Pathways
Biological processes and signaling networks where the ATG16L1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- inflammatory bowel disease
- inflammatory bowel disease type 10
- non-insulin-dependent diabetes mellitus
- pediatric inflammatory bowel disease
- Crohn disease
- dextran sodium sulfate-induced colitis
- streptococcal pharyngitis
- ileitis
- complication
role in cell
- expression in
- accumulation in
- number
- apoptosis
- quantity
- formation
- formation in
- differentiation
- activation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cellular membrane
- lysosome
- Mitochondria
- axonemes
- cytosol
- lysosome membrane
- endosomal membrane
- sperm midpiece
- synapse
- autophagic vacuoles
- organelle membrane contact site
- clathrin-coated vesicles
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATG16L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- positive regulation of autophagy
- protein localization to pre-autophagosomal structure
- protein transport
- defense response to virus
- hippocampus development
- C-terminal protein lipidation
- macroautophagy
- corpus callosum development
- microautophagy
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- pre-autophagosomal structure membrane
- endolysosome membrane
- Atg12-Atg5-Atg16 complex
- cytosol
- autophagic vacuole
- autophagic vacuole membrane
- axoneme
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- GTPase binding
- protein anchor
- small conjugating protein ligase activity