Rgs1 Gene Summary [Mouse]
Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Acts upstream of or within response to bacterium. Predicted to be located in cytoplasmic side of plasma membrane and cytosol. Orthologous to human RGS1 (regulator of G protein signaling 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs1 |
| Official Name | regulator of G-protein signaling 1 [Source:MGI Symbol;Acc:MGI:1354694] |
| Ensembl ID | ENSMUSG00000026358 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 1 |
| Synonyms | 1R20, BL34, HEL-S-87, IER1, IR20, regulator of G-protein signaling 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- calmodulin binding
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Rgs1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- breast cancer
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- diabetes mellitus
- systemic sclerosis
- celiac disease
- diabetic nephropathy
- age-related macular degeneration
role in cell
- expression in
- migration
- number
- adhesion
- function
- downregulation in
- chemotaxis
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cytosol
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- response to bacterium
- negative regulation of signal transduction
- immune response
- G-protein coupled receptor signaling pathway
- signal transduction
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- G-protein alpha-subunit binding
- GTPase activity
- GTPase activator activity