Map3k12 Gene Summary [Mouse]
Enables protein homodimerization activity; protein serine/threonine kinase activator activity; and protein serine/threonine kinase activity. Involved in several processes, including JNK cascade; positive regulation of JUN kinase activity; and protein phosphorylation. Acts upstream of or within negative regulation of motor neuron apoptotic process. Located in cytosol; growth cone; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k12 |
| Official Name | mitogen-activated protein kinase kinase kinase 12 [Source:MGI Symbol;Acc:MGI:1346881] |
| Ensembl ID | ENSMUSG00000023050 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 12 |
| Synonyms | DLK, DLK/MUK, HP09298, MEKK12, mitogen-activated protein kinase kinase kinase 12, MUK, PK, ZPK, ZPKP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map3k12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- nuclear localization sequence
- leucine zipper domain
- protein binding
- Protein kinase domain
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- arginine rich motif
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Map3k12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- STAT3 Pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- slow Wallerian degeneration
- androgenic alopecia
role in cell
- phosphorylation in
- expression in
- quantity
- differentiation
- migration
- apoptosis
- proliferation
- cell death
- activation in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- growth cone
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map3k12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- positive regulation of protein kinase activity
- positive regulation of transcription, DNA-dependent
- positive regulation of ERK1 and ERK2 cascade
- protein autophosphorylation
- JNK cascade
- peptidyl-serine phosphorylation
- protein phosphorylation
- post-translational protein modification
- negative regulation of motor neuron apoptotic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein binding
- protein serine/threonine kinase activator activity
- protein homodimerization activity
- JUN kinase kinase kinase activity
- protein kinase activity
- protein serine/threonine kinase activity