Pcgf6 Gene Summary [Mouse]
Predicted to enable protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Is expressed in central nervous system; eye; limb; trunk somite; and urinary system. Orthologous to human PCGF6 (polycomb group ring finger 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcgf6 |
| Official Name | polycomb group ring finger 6 [Source:MGI Symbol;Acc:MGI:1918291] |
| Ensembl ID | ENSMUSG00000025050 |
| Bio databases IDs | |
| Aliases | polycomb group ring finger 6 |
| Synonyms | 4933407A11Rik, MBLR, polycomb group ring finger 6, RNF134 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcgf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RING-type zinc-finger
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- protein domain specific binding
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Pcgf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- dyslexia
role in cell
- expression in
- assembly
- remodeling
- recruitment in
- palbociclib resistance
- pictilisib resistance
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcgf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding