Tubgcp4 Gene Summary [Mouse]
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in centrosome and recycling endosome. Predicted to be part of gamma-tubulin complex. Is expressed in several structures, including brain ventricular layer; cerebral cortex; and egg cylinder. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 3. Orthologous to human TUBGCP4 (tubulin gamma complex component 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tubgcp4 |
| Official Name | tubulin, gamma complex associated protein 4 [Source:MGI Symbol;Acc:MGI:1196293] |
| Ensembl ID | ENSMUSG00000027263 |
| Bio databases IDs | |
| Aliases | tubulin, gamma complex associated protein 4 |
| Synonyms | 4932441P04Rik, 76P, D2Ertd435e, GCP-4, Grip76, MCCRP3, P53 binding, RGD1306924, tubulin gamma complex component 4, tubulin, gamma complex component 4, tubulin γ complex component 4, tubulin, γ complex component 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tubgcp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Gamma tubulin complex component N-terminal
- Gamma tubulin complex component C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive microcephaly and chorioretinopathy type 3
- growth failure
- microcephaly
role in cell
- proliferation
- assembly
- crizotinib sensitivity
- ciliogenesis in
- electrophysiology
- abnormal morphology
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- centrosome
- cytosol
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tubgcp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle assembly
- meiotic cell cycle
- macromolecular complex assembly
- microtubule nucleation
- cytoplasmic microtubule organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centrosome
- membrane
- equatorial microtubule organizing center
- spindle pole
- cytosol
- gamma-tubulin large complex
- recycling endosome
- gamma-tubulin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule minus-end binding
- gamma-tubulin binding
- structural constituent of cytoskeleton