Osbpl8 Gene Summary [Mouse]
This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Osbpl8 |
| Official Name | oxysterol binding protein-like 8 [Source:MGI Symbol;Acc:MGI:2443807] |
| Ensembl ID | ENSMUSG00000020189 |
| Bio databases IDs | |
| Aliases | oxysterol binding protein-like 8 |
| Synonyms | AA536976, C730029P18Rik, D330025H14RIK, KIAA1451, MST120, MSTP120, ORP-8, OSBP10, oxysterol binding protein-like 8, RGD1561474 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Osbpl8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- cholesterol binding
- binding protein
- phospholipid transporter
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Oxysterol-binding protein
- phosphatidylinositol binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- T-cell non-Hodgkin disease
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- Huntington disease
role in cell
- apoptosis
- expression in
- activation in
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- cortical endoplasmic reticulum
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Osbpl8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of sequestering of triglyceride
- positive regulation of insulin receptor signaling pathway
- protein localization to nuclear pore
- phospholipid transport
- positive regulation of glucose import
- fat cell differentiation
- phosphatidylserine acyl-chain remodeling
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- membrane
- cytosol
- cortical endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- phosphatidylserine binding
- phospholipid transporter activity
- protein binding
- cholesterol binding