Drd4 Gene Summary [Mouse]
Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in regulation of circadian rhythm and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; behavioral response to cocaine; and inhibitory postsynaptic potential. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Drd4 |
| Official Name | dopamine receptor D4 [Source:MGI Symbol;Acc:MGI:94926] |
| Ensembl ID | ENSMUSG00000025496 |
| Bio databases IDs | |
| Aliases | dopamine receptor D4 |
| Synonyms | D4 dopamine receptor, D4DR, D4R, D4RA, D4 Receptor, Dopamine receptor 4, dopamine receptor D4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Drd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- protein repeat
- hormone binding
- intracellular loop
- protein binding
- tandem repeat
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- SH3-domain binding
- Sh3 domain binding motif
- dopamine D2 receptor-like receptor
- binding protein
- cytoplasmic domain
- cytoplasmic loop
- dopamine receptor
- 7 transmembrane receptor (rhodopsin family)
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Drd4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic gastric cancer
- gastric cancer
- end stage renal disease
- undernutrition
- refractory schizophrenia
- schizophrenia
- bipolar depression
- bipolar disorder
- schizoaffective disorder
- overweight disorder
role in cell
- expression in
- production in
- cellular infiltration by
- apoptosis
- phosphorylation in
- activity
- activation in
- synaptic transmission
- morphology
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- cell periphery
- cellular membrane
- cell cortex
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- cytoplasmic face of plasma membrane
- presynaptic membrane
- postsynaptic membrane
- dendritic spines
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- dendritic shafts
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Drd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- dopamine metabolic process
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
- adenylate cyclase-inhibiting dopamine receptor signaling pathway
- dopamine receptor signaling pathway
- adult locomotory behavior
- fear response
- regulation of circadian rhythm
- synaptic transmission, dopaminergic
- positive regulation of dopamine uptake involved in synaptic transmission
- behavioral response to cocaine
- positive regulation of kinase activity
- social behavior
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of protein secretion
- synaptic transmission
- behavioral response to ethanol
- cellular calcium ion homeostasis
- behavioral fear response
- positive regulation of sodium:hydrogen antiporter activity
- rhythmic process
- response to amphetamine
- arachidonic acid secretion
- regulation of dopamine metabolic process
- response to histamine
- regulation of inhibitory postsynaptic membrane potential
Cellular Component
Where in the cell the gene product is active
- dendrite
- centrosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- dopamine binding
- dopamine receptor activity, coupled via Gi/Go
- norepinephrine binding
- serotonin receptor activity
- serotonin binding
- dopamine receptor activity
- epinephrine binding
- protein binding
- metal ion binding
- neurotransmitter receptor activity
- SH3 domain binding
- potassium channel regulator activity