Med28 Gene Summary [Mouse]
Predicted to enable actin binding activity. Acts upstream of or within negative regulation of smooth muscle cell differentiation and somatic stem cell population maintenance. Located in cortical actin cytoskeleton. Is expressed in several structures, including alimentary system; eye; male reproductive gland or organ; nervous system; and neural ectoderm. Orthologous to human MED28 (mediator complex subunit 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med28 |
| Official Name | mediator complex subunit 28 [Source:MGI Symbol;Acc:MGI:1914249] |
| Ensembl ID | ENSMUSG00000015804 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 28 |
| Synonyms | 1500003D12Rik, EG1, FKSG20, magicin, mediator complex subunit 28, RGD1305875 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mediator complex subunit 28
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- productive infection by HIV-1
role in cell
- cell death
- expression in
- proliferation
- differentiation
- transcription in
- replication in
- transdifferentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cortical actin cytoskeleton
- cytoskeleton
- Cytoplasm
- cellular membrane
- actin cytoskeleton
- actin filaments
- nucleoplasm
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- somatic stem cell maintenance
- negative regulation of smooth muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- membrane
- mediator complex
- cortical actin cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding