Spta1 Gene Summary [Rat]
Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within several processes, including lymphocyte homeostasis; porphyrin-containing compound biosynthetic process; and positive regulation of T cell proliferation. Located in axon and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in hereditary pyropoikilocytosis; hereditary spherocytosis; and hereditary spherocytosis type 3. Orthologous to human SPTA1 (spectrin alpha, erythrocytic 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spta1 |
| Official Name | spectrin, alpha, erythrocytic 1 [Source:RGD Symbol;Acc:1305194] |
| Ensembl ID | ENSRNOG00000003537 |
| Bio databases IDs | |
| Aliases | spectrin, alpha, erythrocytic 1 |
| Synonyms | alpha1 SPECTRIN, EL2, Erythroid Alpha-Spectrin, Erythroid α-Spectrin, ha, HPP, HS3, ihj, nmf4, Spectrin alpha 1, spectrin alpha, erythrocytic 1, spectrin, alpha, erythrocytic 1, Spectrin α 1, spectrin α, erythrocytic 1, spectrin, α, erythrocytic 1, sph, SPH3, Spna-1, SPTA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spta1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- actin filament binding
- EF-Hand
- Spectrin repeats
- chromosome segregation protein SMC, common bacterial type
- spectrin homology domain
- structural constituent of cytoskeleton
- Spectrin repeat
- EFh
- protein binding
- Ca2+ insensitive EF hand
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Spta1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- elliptocytosis type 2
- hemolytic anemia
- hereditary pyropoikilocytosis
- congenital hemolytic anemia
- autosomal recessive spherocytosis type 3
- hereditary spherocytosis
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- hemolysis
role in cell
- quantity
- proliferation
- organization
- hematopoiesis
- volume
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- cortical cytoskeleton
- cytoskeleton
- cellular membrane
- actin cytoskeleton
- Nucleus
- vesicles
- Golgi Apparatus
- cytosol
- cytoplasmic face of plasma membrane
- cuticular plate
- multivesicular bodies
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spta1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- plasma membrane organization
- porphyrin-containing compound biosynthetic process
- actin filament capping
- hemopoiesis
- lymphocyte homeostasis
- actin filament organization
- positive regulation of T cell proliferation
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- cytosol
- cell junction
- spectrin
- cuticular plate
- cell projection
- plasma membrane
- cortical actin cytoskeleton
- axon
- internal side of plasma membrane
- spectrin-associated cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- calcium ion binding
- structural constituent of cytoskeleton