Fanca Gene Summary [Mouse]
Acts upstream of or within several processes, including gonad development; regulation of CD40 signaling pathway; and regulation of regulatory T cell differentiation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in several structures, including brain; gut; liver; reproductive system; and spleen. Used to study Fanconi anemia complementation group A. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); cervical cancer; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Orthologous to human FANCA (FA complementation group A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fanca |
| Official Name | Fanconi anemia, complementation group A [Source:MGI Symbol;Acc:MGI:1341823] |
| Ensembl ID | ENSMUSG00000032815 |
| Bio databases IDs | |
| Aliases | Fanconi anemia, complementation group A |
| Synonyms | FA, FA1, FAA, FACA, FA complementation group A, FA-H, FANCH, Fanconi anaemia, complementation group A, Fanconi anemia, complementation group A, LOC103690042 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fanca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fancg binding domain
- Fanconi anaemia group A protein
- partial leucine zipper motif
- nuclear localization sequence
- leucine zipper domain
- protein binding
- Fanconi anaemia group A protein N terminus
Pathways
Biological processes and signaling networks where the Fanca gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- epithelial cancer
- cancer
- Fanconi anemia, group A
- Fanconi anemia
- metastasis
- schizophrenia
- hereditary disorder
- epithelial basal cell carcinoma
- esophageal squamous cell carcinoma
role in cell
- activation in
- accumulation in
- apoptosis
- expression in
- proliferation
- growth
- cell viability
- survival
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- membrane fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fanca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- male gonad development
- macromolecular complex assembly
- male meiosis
- regulation of inflammatory response
- regulation of regulatory T cell differentiation
- female gonad development
- regulation of CD40 signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- Fanconi anaemia nuclear complex
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding