Fcgr2b Gene Summary [Mouse]
Enables IgG binding activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; nervous system development; and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is expressed in several structures, including adipose tissue; bone; liver; lung; and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2A (Fc gamma receptor IIa) and FCGR2B (Fc gamma receptor IIb). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fcgr2b |
| Official Name | Fc receptor, IgG, low affinity IIb [Source:MGI Symbol;Acc:MGI:95499] |
| Ensembl ID | ENSMUSG00000026656 |
| Bio databases IDs | |
| Aliases | Fc receptor, IgG, low affinity IIb |
| Synonyms | CD32, CD32b, F630109E10Rik, Fc Gamma 2a, Fc gamma R2, Fcgr2, Fcgr2a, FcgRII, Fc[g]RII, Fcgr γ Chain, Fcr-2, Fcr-3, FC receptor, IgG, low affinity IIb, FC receptor, IgG, low afinity IIb, fcRII, Fc γ 2a, Fc γ R2, Fc-γ-RII, FC γ R II B, Ly-17, LyM-1, Ly-m20 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fcgr2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C1q binding domain
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- low affinity IgG receptor
- protein binding
- beta-amyloid binding
- immunoglobulin binding
- T-cell surface glycoprotein CD3 delta chain
- binding protein
- IgG binding
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- Fcgr1 binding domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Fcgr2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Parkinson's Signaling Pathway
- Phagosome Formation
- Phospholipase C Signaling
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- insulin-dependent diabetes mellitus
- collagen-induced arthritis
- adjuvant arthritis
- thrombocytopenia
- glomerulonephritis
- arthritis
- anaphylaxis
- systemic lupus erythematosus
- anemia
role in cell
- production in
- phosphorylation in
- activation in
- expression in
- proliferation
- apoptosis
- accumulation
- binding
- differentiation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- cell surface
- cellular membrane
- plasma membrane extracellular face
- dendritic spines
- recycling endosomes
- membrane rafts
- perikaryon