Esrrg Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and estrogen response element binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esrrg |
| Official Name | estrogen-related receptor gamma [Source:MGI Symbol;Acc:MGI:1347056] |
| Ensembl ID | ENSMUSG00000026610 |
| Bio databases IDs | |
| Aliases | estrogen-related receptor gamma |
| Synonyms | ERR3, ERRg, ERRG2, ERR-gamma, ERR-γ, estrogen-related receptor gamma, estrogen-related receptor-γ, KIAA0832, LOC100504550, mKIAA0832, NR3B3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esrrg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- AF-2 domain binding
- DNA binding domain
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- nucleic acid binding
- AF-2 transcription activation domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- hormone binding domain
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- ligand-binding domain
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- alcoholism
- major depression
- autism
- idiopathic scoliosis
- Duchenne muscular dystrophy
- chronic kidney disease
- Huntington disease
- prostate cancer
- uterine leiomyoma
role in cell
- expression in
- phosphorylation in
- activation in
- growth
- G1/S phase transition
- differentiation
- production in
- formation
- maturation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esrrg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoic acid receptor signaling pathway
- intracellular steroid hormone receptor signaling pathway
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- AF-2 domain binding
- estrogen response element binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- steroid binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity