Adcy4 Gene Summary [Mouse]
Predicted to enable G-protein beta/gamma-subunit complex binding activity; adenylate cyclase activity; and protein kinase C binding activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in dendrite. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy4 |
| Official Name | adenylate cyclase 4 [Source:MGI Symbol;Acc:MGI:99674] |
| Ensembl ID | ENSMUSG00000022220 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 4 |
| Synonyms | AC4, adenylate cyclase 4, mKIAA4004 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adcy4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- adenylate cyclase
- protein kinase C binding
- Class III nucleotidyl cyclases
- enzyme
- protein binding
- Adenylyl- / guanylyl cyclase, catalytic domain
- Adenylate cyclase, conserved domain
Pathways
Biological processes and signaling networks where the Adcy4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Gustation Pathway
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- lymphomagenesis
- necrotizing enterocolitis
- primary central nervous system lymphoma
- primary cancer
- central nervous system cancer
- Dupuytren contracture
regulates
- cyclic AMP
role in cell
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cilia
- intracellular space
- cellular membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adcy4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cAMP biosynthetic process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- ATP binding
- protein binding
- metal ion binding
- adenylate cyclase activity