Crebzf Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including early embryo; foot mesenchyme; nervous system; retina; and uterus. Orthologous to human CREBZF (CREB/ATF bZIP transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crebzf |
| Official Name | CREB/ATF bZIP transcription factor [Source:MGI Symbol;Acc:MGI:2675296] |
| Ensembl ID | ENSMUSG00000051451 |
| Bio databases IDs | |
| Aliases | CREB/ATF bZIP transcription factor |
| Synonyms | 1110034C16RIK, 6330417B10RIK, AI225749, AI606244, CREB/ATF bZIP transcription factor, HCF-binding TRANSCRIPTION FACTOR ZHANGFEI, LAZip, LAZipII, RGD1565584, SMILE, ZF, Zhangfei |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crebzf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- protein binding
- identical protein binding
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Crebzf gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- collagen-induced arthritis
- adult T-cell leukemia/lymphoma
- melanoma
- melanoma cancer
- memory deficits
- collagen antibody-induced arthritis
role in cell
- proliferation
- expression in
- dimerization in
- binding in
- degradation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- punctate structures
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crebzf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- response to virus
- regulation of transcription from RNA polymerase II promoter
- regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity