Crtc2 Gene Summary [Mouse]
Predicted to enable cAMP response element binding protein binding activity; chromatin binding activity; and transcription coactivator activity. Involved in gluconeogenesis; glucose homeostasis; and positive regulation of CREB transcription factor activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; ear; integumental system; limb; and nervous system. Orthologous to human CRTC2 (CREB regulated transcription coactivator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crtc2 |
| Official Name | CREB regulated transcription coactivator 2 [Source:MGI Symbol;Acc:MGI:1921593] |
| Ensembl ID | ENSMUSG00000027936 |
| Bio databases IDs | |
| Aliases | CREB regulated transcription coactivator 2 |
| Synonyms | 4632407F12Rik, CREB regulated transcription coactivator 2, MTORC2, RGD1308903, TORC-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crtc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transducer of regulated CREB activity middle domain
- Transducer of regulated CREB activity, C terminus
- chromatin binding
- protein binding
- Transducer of regulated CREB activity, N terminus
- phosphorylation site
Pathways
Biological processes and signaling networks where the Crtc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- photothrombotic stroke
- schizophrenia
- hypersomnia
- insulin resistance
- epithelial cancer
- ovarian cancer
- prostatic carcinoma
- prostate cancer
- neurological disorder
role in cell
- proliferation
- apoptosis
- phosphorylation in
- chemotaxis
- expression in
- activation in
- growth
- differentiation
- survival
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crtc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- protein homotetramerization
- glucose homeostasis
- positive regulation of CREB transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding protein binding
- protein binding