Pcdh20 Gene Summary [Mouse]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in cell adhesion in the nervous system and has been shown to be specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. In adult mice, the expression of this protein in the olfactory system is more restricted but shows a gender difference with higher expression in the male than in the female. [provided by RefSeq, Sep 2009]

Details

Type
Protein Coding
Official Symbol
Pcdh20
Official Name
protocadherin 20 [Source:MGI Symbol;Acc:MGI:2443376]
Ensembl ID
ENSMUSG00000050505
Bio databases IDs NCBI: 219257 Ensembl: ENSMUSG00000050505
Aliases protocadherin 20
Synonyms C630015B17RIK, PCDH13, protocadherin 20
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcdh20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin repeat-like domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Crohn disease
  • dextran sodium sulfate-induced colitis
  • Parkinson disease
  • TNBS-induced colitis
regulated by
role in cell
  • proliferation
  • expression in
  • differentiation
  • paracellular permeability
  • disruption
  • transepithelial electrical resistance

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcdh20 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell adhesion
  • homophilic cell adhesion

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • calcium ion binding

Gene-Specific Assays for Results You Can Trust

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