Fmo3 Gene Summary [Mouse]
Predicted to enable NADP binding activity; amino acid binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in taurine biosynthetic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmo3 |
| Official Name | flavin containing monooxygenase 3 [Source:MGI Symbol;Acc:MGI:1100496] |
| Ensembl ID | ENSMUSG00000026691 |
| Bio databases IDs | |
| Aliases | flavin containing monooxygenase 3 |
| Synonyms | dJ127D3.1, flavin containing dimethylaniline monoxygenase 3, flavin containing monooxygenase 3, FMO form 2, FMOII, TMAU |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmo3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP binding
- Pyridine nucleotide-disulphide oxidoreductase
- NAD(P)-binding Rossmann-like domain
- enzyme
- glutamine-fructose-6-phosphate transaminase (isomerizing)
- Flavin-binding monooxygenase-like
- protein binding
- hypotaurine dehydrogenase
- dimethylaniline monooxygenase (N-oxide-forming)
- amino acid binding
Pathways
Biological processes and signaling networks where the Fmo3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- trimethylaminuria
- atherosclerosis
- hereditary disorder
- mild trimethylaminuria
role in cell
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum membrane
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmo3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- taurine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- NADP binding
- protein binding
- flavin adenine dinucleotide binding
- hypotaurine dehydrogenase activity
- albendazole monooxygenase activity
- trimethylamine monooxygenase activity
- N,N-dimethylaniline monooxygenase activity