Mllt10 Gene Summary [Mouse]
Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mllt10 |
| Official Name | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [Source:MGI Symbol;Acc:MGI:1329038] |
| Ensembl ID | ENSMUSG00000026743 |
| Bio databases IDs | |
| Aliases | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 |
| Synonyms | AF10, B130021D15Rik, D630001B22RIK, mKIAA4140, MLLT10 histone lysine methyltransferase DOT1L cofactor, MLLT10, histone lysine methyltransferase DOT1L cofactor, myeloid/lymphoid or mixed-lineage leukaemia; translocated to, 10, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mllt10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription regulator
- nuclear localization sequence
- leucine zipper domain
- chromatin binding
- protein binding
- zDHHC ankyrin repeat binding domain
- PHD-finger
- PHD-like zinc-binding domain
- binding protein
- AT hook domain
- PHD finger superfamily
- PHD-zinc-finger like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- precursor B-cell acute lymphoblastic leukemia
- restless legs syndrome
- acute myeloid leukemia
- kidney carcinoma
- renal cancer
- epithelial cancer
- migraines
- renal clear cell adenocarcinoma
role in cell
- differentiation
- transformation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mllt10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- histone binding
- nucleosome binding
- chromatin binding